| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 20/02/25 18.45 | FK Bodö/Glimt | FC Twente Enschede | 5:2d.t.s |
| 20/02/25 18.45 | FCSB Bukarest | PAOK Salonicco | 2:0 |
| 20/02/25 18.45 | Galatasaray Istanbul | AZ Alkmaar | 2:2 |
| 20/02/25 18.45 | Roma | FC Porto | 3:2 |
| 20/02/25 21.00 | RSC Anderlecht | Fenerbahce Istanbul | 2:2 |
| 20/02/25 21.00 | Ajax Amsterdam | Royale Union Saint-Gilloise | 1:2d.t.s |
| 20/02/25 21.00 | Real Sociedad | FC Midtjylland | 5:2 |
| 20/02/25 21.00 | Viktoria Pilsen | Ferencvaros Budapest | 3:0 |