| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 11/12/24 16.30 | Fenerbahce Istanbul | Athletic Bilbao | 0:2 |
| 12/12/24 18.45 | Malmö FF | Galatasaray Istanbul | 2:2 |
| 12/12/24 18.45 | Roma | Sporting Braga | 3:0 |
| 12/12/24 18.45 | PAOK Salonicco | Ferencvaros Budapest | 5:0 |
| 12/12/24 18.45 | Olympiacos Pireo | FC Twente Enschede | 0:0 |
| 12/12/24 18.45 | Royale Union Saint-Gilloise | OGC Nizza | 2:1 |
| 12/12/24 18.45 | PFC Ludogorets Razgrad | AZ Alkmaar | 2:2 |
| 12/12/24 18.45 | Viktoria Pilsen | Manchester United | 1:2 |
| 12/12/24 18.45 | 1899 Hoffenheim | FCSB Bukarest | 0:0 |
| 12/12/24 21.00 | Glasgow Rangers | Tottenham Hotspur | 1:1 |
| 12/12/24 21.00 | FC Porto | FC Midtjylland | 2:0 |
| 12/12/24 21.00 | Slavia Praga | RSC Anderlecht | 1:2 |
| 12/12/24 21.00 | Ajax Amsterdam | Lazio | 1:3 |
| 12/12/24 21.00 | Maccabi Tel Aviv | Rigas Futbola Skola | 2:1 |
| 12/12/24 21.00 | Real Sociedad | Dynamo Kiev | 3:0 |
| 12/12/24 21.00 | Olympique Lione | Eintracht Francoforte | 3:2 |
| 12/12/24 21.00 | FK Bodö/Glimt | Besiktas Istanbul | 2:1 |
| 12/12/24 21.00 | IF Elfsborg Boras | Qarabag | 1:0 |