| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 12/02/19 18.55 | Fenerbahce Istanbul | Zenit San Pietroburgo | 1:0 |
| 14/02/19 18.55 | Stade Rennes | Real Betis Siviglia | 3:3 |
| 14/02/19 18.55 | Galatasaray Istanbul | Benfica Lisbona | 1:2 |
| 14/02/19 18.55 | BATE Barisov | FC Arsenal | 1:0 |
| 14/02/19 18.55 | Lazio | FC Siviglia | 0:1 |
| 14/02/19 18.55 | FK Krasnodar | Bayer 04 Leverkusen | 0:0 |
| 14/02/19 18.55 | SK Rapid Vienna | Inter | 0:1 |
| 14/02/19 18.55 | Slavia Praga | KRC Genk | 0:0 |
| 14/02/19 18.55 | Olympiacos Pireo | Dynamo Kiev | 2:2 |
| 14/02/19 21.00 | Sporting Lisbona | FC Villarreal | 0:1 |
| 14/02/19 21.00 | Viktoria Pilsen | Dinamo Zagabria | 2:1 |
| 14/02/19 21.00 | Club Brügge | FC Red Bull Salisburgo | 2:1 |
| 14/02/19 21.00 | Malmö FF | FC Chelsea | 1:2 |
| 14/02/19 21.00 | Shakhtar Donezk | Eintracht Francoforte | 2:2 |
| 14/02/19 21.00 | FC Zurigo | SSC Napoli | 1:3 |
| 14/02/19 21.00 | Celtic Glasgow | FC Valencia | 0:2 |