| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 21/05/22 21.00 | OSC Lille | Stade Rennes | 2:2 |
| 21/05/22 21.00 | FC Lorient | ES Troyes AC | 1:1 |
| 21/05/22 21.00 | Olympique Marsiglia | Racing Club Strasburgo | 4:0 |
| 21/05/22 21.00 | FC Nantes | AS St. Etienne | 1:1 |
| 21/05/22 21.00 | Paris St. Germain | FC Metz | 5:0 |
| 21/05/22 21.00 | Stade Reims | OGC Nizza | 2:3 |
| 21/05/22 21.00 | SCO Angers | HSC Montpellier | 2:0 |
| 21/05/22 21.00 | Stade Brest 29 | Girondins Bordeaux | 2:4 |
| 21/05/22 21.00 | Clermont Foot | Olympique Lione | 1:2 |
| 21/05/22 21.00 | RC Lens | AS Monaco | 2:2 |