| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 18/05/21 21.15 | CD Tondela | FC Pacos de Ferreira | 2:3 |
| 19/05/21 19.00 | FC Porto | Belenenses Lisbona | 4:0 |
| 19/05/21 21.00 | SC Portimonense | Sporting Braga | 0:0 |
| 19/05/21 21.00 | Moreirense FC | FC Famalicao | 3:0 |
| 19/05/21 21.00 | Nacional Funchal | Rio Ave FC | 1:2 |
| 19/05/21 21.00 | CD Santa Clara | SC Farense | 4:0 |
| 19/05/21 21.00 | FC Gil Vicente | Boavista Porto | 1:2 |
| 19/05/21 21.00 | Vitoria Guimaraes | Benfica Lisbona | 1:3 |
| 19/05/21 22.45 | Sporting Lisbona | Maritimo Funchal | 5:1 |