| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 11/03/18 14.30 | KV Mechelen | Waasland-Beveren | 2:0 |
| 11/03/18 14.30 | KRC Genk | KAA Gent | 1:2 |
| 11/03/18 14.30 | Sint-Truidense VV | Club Brügge | 0:1 |
| 11/03/18 14.30 | KV Oostende | Standard Liegi | 2:3 |
| 11/03/18 14.30 | KV Kortrijk | Sporting Charleroi | 2:0 |
| 11/03/18 14.30 | KAS Eupen | Royal Excel Mouscron | 4:0 |
| 11/03/18 14.30 | KSC Lokeren OV | SV Zulte-Waregem | 0:2 |
| 11/03/18 14.30 | RSC Anderlecht | Royal Antwerp FC | 2:1 |