| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 01/06/18 21.00 | La Hoya Lorca | Sevilla Atlético | 2:1 |
| 02/06/18 20.30 | CD Teneriffa | Albacete Balompie | 1:1 |
| 02/06/18 20.30 | AD Alcorcon | CF Reus Deportiu | 3:0 |
| 02/06/18 20.30 | Real Oviedo | SD Huesca | 2:1 |
| 02/06/18 20.30 | Cordoba CF | Sporting Gijon | 3:0 |
| 02/06/18 20.30 | FC Barcellona B | Real Saragossa | 0:2 |
| 02/06/18 20.30 | CD Lugo | UD Almeria | 1:1 |
| 02/06/18 20.30 | Gimnastic de Tarragona | Rayo Vallecano | 2:0 |
| 02/06/18 20.30 | CD Numancia | Cultural y Deportiva Leonesa | 2:1 |
| 02/06/18 20.30 | Real Valladolid | CA Osasuna | 2:0 |
| 02/06/18 20.30 | FC Granada | FC Cadiz | 2:1 |