| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 27/05/22 21.00 | Real Sociedad B | Real Saragossa | 1:2 |
| 27/05/22 21.00 | CD Mirandes | CF Fuenlabrada | 5:1 |
| 28/05/22 18.15 | SD Amorebieta | SD Ponferradina | 1:0 |
| 28/05/22 18.15 | CD Lugo | FC Malaga | 1:0 |
| 29/05/22 20.00 | Burgos CF | FC Girona | 0:0 |
| 29/05/22 20.00 | CD Leganes | UD Almeria | 2:2 |
| 29/05/22 20.00 | Real Oviedo | UD Ibiza Eivissa | 3:2 |
| 29/05/22 20.00 | Sporting Gijon | UD Las Palmas | 0:1 |
| 29/05/22 20.00 | AD Alcorcon | SD Eibar | 1:0 |
| 29/05/22 20.00 | CD Teneriffa | FC Cartagena | 1:2 |
| 29/05/22 20.00 | Real Valladolid | SD Huesca | 3:0 |