| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 29/05/21 18.30 | CD Teneriffa | Real Oviedo | 2:2 |
| 30/05/21 18.30 | Albacete Balompie | CF Fuenlabrada | 1:2 |
| 30/05/21 21.00 | CD Mirandes | CD Sabadell | 0:2 |
| 30/05/21 21.00 | FC Cartagena | FC Girona | 1:1 |
| 30/05/21 21.00 | Rayo Vallecano | CD Lugo | 0:1 |
| 30/05/21 21.00 | FC Malaga | CD Castellon | 3:0 |
| 30/05/21 21.00 | SD Ponferradina | RCD Mallorca | 2:2 |
| 30/05/21 21.00 | AD Alcorcon | Espanyol Barcellona | 1:0 |
| 30/05/21 21.00 | UD Logrones | UD Las Palmas | 0:1 |
| 30/05/21 21.00 | Real Saragossa | CD Leganes | 0:5 |
| 30/05/21 21.00 | Sporting Gijon | UD Almeria | 0:2 |