| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 16/05/21 14.30 | PEC Zwolle | FC Groningen | 1:0 |
| 16/05/21 14.30 | VVV Venlo | FC Emmen | 0:4 |
| 16/05/21 14.30 | AZ Alkmaar | Heracles Almelo | 5:0 |
| 16/05/21 14.30 | SC Heerenveen | Sparta Rotterdam | 1:2 |
| 16/05/21 14.30 | FC Utrecht | PSV Eindhoven | 1:1 |
| 16/05/21 14.30 | FC Twente Enschede | ADO Den Haag | 3:2 |
| 16/05/21 14.30 | Feyenoord Rotterdam | RKC Waalwijk | 3:0 |
| 16/05/21 14.30 | Willem II Tilburg | Fortuna Sittard | 2:1 |
| 16/05/21 14.30 | Vitesse Arnheim | Ajax Amsterdam | 1:3 |