| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 08/05/16 14.30 | FC Utrecht | AZ Alkmaar | 1:3 |
| 08/05/16 14.30 | Feyenoord Rotterdam | NEC Nijmwegen | 1:0 |
| 08/05/16 14.30 | PEC Zwolle | PSV Eindhoven | 1:3 |
| 08/05/16 14.30 | De Graafschap Doetinchem | Ajax Amsterdam | 1:1 |
| 08/05/16 14.30 | FC Twente Enschede | Vitesse Arnheim | 2:2 |
| 08/05/16 14.30 | Roda JC Kerkrade | Willem II Tilburg | 2:3 |
| 08/05/16 14.30 | FC Groningen | Heracles Almelo | 2:1 |
| 08/05/16 14.30 | Cambuur-Leeuwarden | Excelsior Rotterdam | 0:2 |
| 08/05/16 14.30 | ADO Den Haag | SC Heerenveen | 1:1 |