| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 15/05/22 14.30 | FC Groningen | Cambuur-Leeuwarden | 2:3 |
| 15/05/22 14.30 | NEC Nijmwegen | Fortuna Sittard | 0:1 |
| 15/05/22 14.30 | SC Heerenveen | Go Ahead Eagles Deventer | 3:1 |
| 15/05/22 14.30 | Feyenoord Rotterdam | FC Twente Enschede | 1:2 |
| 15/05/22 14.30 | AZ Alkmaar | RKC Waalwijk | 1:3 |
| 15/05/22 14.30 | Heracles Almelo | Sparta Rotterdam | 1:3 |
| 15/05/22 14.30 | Vitesse Arnheim | Ajax Amsterdam | 2:2 |
| 15/05/22 14.30 | PEC Zwolle | PSV Eindhoven | 1:2 |
| 15/05/22 14.30 | Willem II Tilburg | FC Utrecht | 3:0 |